NCT00392327

Clinical Trial Information


Trial Number: NCT00392327 (ClinicalTrials.gov)
Disease Type:
  • CNS Neoplasm (Primary Tumor) - Embryonal Tumors
Trial Title:
Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients
Study ID:
ACNS0332
Images are available?:
Yes
Is this a NCI-MATCH Trial?:
No


Datasets Linked to Trial

Title Description
NCT00392327-D3 As of November 2019, there is only one dataset associated with this publication (PMID 31601576). This dataset contains patient characteristics (age and sex), magnetic resonance imaging (MRI) features, methylation profiling results, and event-free survival data for patients with institutionally diagnosed supratentorial primitive neuroectodermal tumors of the CNS (CNS-PNETs) and pineoblastomas (PBLs) who were enrolled on ACNS0332 and had molecular classification by DNA methylation and imaging data. Of the 85 patients with institutionally diagnosed CNS-PNET/pineoblastoma enrolled and randomized on ACNS0332, 56 met the inclusion criteria for this manuscript.

The data from the ACNS0332 primary publication (PMID 30332335) can be found in NCT00392327-D1 and -D2.
NCT00392327-D2 NCT00392327-D2-Dataset
The second dataset (D2) contains data provided by the central pathologist on the 10 patients who were selected for a second central pathology review, given the discrepancies between profiling and centrally reviewed histopathologic diagnoses. This second central pathology review was done at the request of one of the journal article reviewers. The text in the results section of the manuscript and the associated data are geared towards pathologists rather than the general readership.
NCT00392327-D1 NCT00392327-D1-Dataset
As of June 2019, there are two datasets associated with this publication (PMID 30332335). The first dataset (D1) contains patient characteristics, toxicity, methylation profiling results and primary outcome analyses for the subset of patients with institutionally diagnosed supratentorial primitive neuroectodermal tumors of the CNS (CNS-PNETs) and pineoblastomas (PBLs) who were enrolled on ACNS0332 as reported in the manuscript (n=85).